{"ok":true,"nota":{"id":"008ec827a577ca3c","slug":"eliminar-una-proteina-hace-que-tumores-de-colon-mueran-por-oxidacion-e-008ec8","titulo":"Eliminar una proteína hace que tumores de colon mueran por oxidación en ratones","resumen":"Investigadores borraron el gen de la proteína CBX3 en células de cáncer de colon y en ratones. Vieron que las células sin esa proteína se oxidaban y morían más por ferroptosis, sobre todo al estimularlas con interferón gamma.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Xiang, Y., Fu, Y., Desterke, C., Batsche, E., Jalil, A., Elhage, R., Duruel, C., Beche, J.-C., Frapy, E., Skurnik, D., R","url":"https://www.biorxiv.org/content/10.64898/2026.10.23.761323v1?rss=1","imagen":"/hoy/portada/008ec827a577ca3c","tema":"salud","subtemas":["cáncer colorrectal","ferroptosis","oncología","epigenética","terapias experimentales"],"entidades":["bioRxiv","CBX3","SLC7A11","ratones MC38"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-27T00:00:00.000Z","indexTs":"2026-10-27T13:32:50.787Z","hash":"aa158026987f6dd5736d602761f581b6e0ddc08ab58beaff814a31f99fd3ce8c","tsa":{"time":"Oct 27 13:33:56 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Los tumores de colon a veces esquivan los tratamientos porque se protegen del daño oxidativo, y este trabajo muestra una forma de sacarles esa defensa. Para un paciente con cáncer colorrectal, la idea abre una vía nueva si se confirma en personas. Por ahora es un hallazgo en células y ratones, y no hay ningún tratamiento disponible. Sin estudios clínicos, la distancia entre el laboratorio y la consulta sigue siendo muy grande.","quienFirma":"Universidad (investigación en oncología, bioRxiv)","confianza":"preprint","consulta":null},"sello":{"hash":"aa158026987f6dd5736d602761f581b6e0ddc08ab58beaff814a31f99fd3ce8c","sello":"2bfb8d4d2b7d463acb4a87546923b4a1bfffc62a979677685944b55c1e2b7a8b","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6589233,"aleatorio":"9e3771ddc58969f14f5a222bb9b7094431610becfbf31158b3d02257e478abf8","tiempo":"2026-10-27T13:33:30.000Z"},"nist":{"cadena":2,"pulso":2001772,"salida":"0E703280D2ECB99CF237148891BE4B05125CA4A9FA93BA99C93DE108693398FC1C1436A917C2E942D3FD99D4FACCDDC40E70589522F4EEDE9B18514294B0BD55","tiempo":"2026-10-27T12:55:00.000Z"},"noAntes":"2026-10-27T13:33:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 27 13:33:56 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"CBX3 Deletion Overcomes Ferroptosis Resistance in Colorectal Cancer by Targeting IFNγ/SLC7A11/SLC3A2 Axis","descripcion":"System Xc- (SLC7A11/SLC3A2) maintains redox balance by supporting glutathione synthesis, thereby preventing lipid peroxidation and ferroptosis, and represents a promising therapeutic target in cancer. In this work, we revealed that an important epigenetic regulator, CBX3 deletion significantly increased intracellular ROS and lipid ROS level following ferroptosis inducing, particularly under IFN{gamma} stimulation, thereby sensitized CRC cells to ferroptosis in vitro using human CRC cells as well as in vivo using MC38 syngenetic tumors. RNAseq with mice syngeneic tumors revealed an 11-gene oxidative stress signature downregulated in Cbx3KO tumors after combined treatment; its low expression s","pubDate":"2026-10-27","url":"https://www.biorxiv.org/content/10.64898/2026.10.23.761323v1?rss=1"},"indexado":"2026-10-27T13:32:50.787Z"}}