{"ok":true,"nota":{"id":"005e9dd06f405d68","slug":"un-solo-analisis-de-sangre-distingue-alzheimer-parkinson-y-esclerosis--005e9d","titulo":"Un solo análisis de sangre distingue Alzheimer, Parkinson y esclerosis lateral con buena precisión","resumen":"Un equipo de Tokio usó un panel de proteínas en plasma sobre 302 personas, con controles sanos y pacientes con Alzheimer, Parkinson o esclerosis lateral amiotrófica. Aplicaron modelos estadísticos específicos para cada enfermedad y evaluaron si el panel las diferenciaba.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"Okada, K., Shimohama, S., Okochi, R., Bun, S., Takahata, K., Tabuchi, H., Iwabuchi, Y., Tezuka, T., Nukariya, T., Okusa,","url":"https://www.medrxiv.org/content/10.64898/2026.10.19.26365782v1?rss=1","imagen":"/hoy/portada/005e9dd06f405d68","tema":"salud","subtemas":["biomarcadores","alzheimer","parkinson","esclerosis lateral amiotrófica","diagnóstico en sangre"],"entidades":["Universidad Keio","Tokio","Olink"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-21T00:00:00.000Z","indexTs":"2026-10-22T04:37:56.220Z","hash":"b497fe02ee2326a61cb04fc2236c0a58b4e882dbe50031ba0e7c30b99c3c1130","tsa":{"time":"Oct 22 04:38:37 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"motor","registro":"hallazgo","porQueImporta":"Hoy diagnosticar estas enfermedades suele requerir estudios caros y especializados, y muchas veces llega tarde. Un análisis de sangre que sirva para varias a la vez podría acortar el camino hasta un diagnóstico en hospitales de la Argentina. El estudio es de un solo centro y con muestra chica para cada grupo, así que todavía hace falta comprobarlo en otros pacientes.","quienFirma":"Universidad Keio, Hospital Universitario Keio","confianza":"preprint","consulta":{"pregunta":"¿Te gustaría que un análisis de sangre reemplace a algunos estudios costosos para diagnosticar enfermedades neurológicas"}},"sello":{"hash":"b497fe02ee2326a61cb04fc2236c0a58b4e882dbe50031ba0e7c30b99c3c1130","sello":"9bc286a6ca8b475a088823985ba637ef713836190e607f1f83f763932125b8bb","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6573763,"aleatorio":"ac1ab9766ef209323093f9521e7402b29370fa8f04af200361451518fae9c9b2","tiempo":"2026-10-22T04:38:30.000Z"},"nist":{"cadena":2,"pulso":1994087,"salida":"2CAE0B0247F8B2C1365D5848B4971A88B86F8096596AB659C9B46851CC37B71B43230BE62392778D57CA4D0DAE3440419DC67D4E27A84A89E3AA5B314736F2A3","tiempo":"2026-10-22T04:38:00.000Z"},"noAntes":"2026-10-22T04:38:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 22 04:38:37 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Plasma Proteomic Classification of Alzheimer Disease, Parkinson Disease, and Amyotrophic Lateral Sclerosis Using a Single Neurodegeneration Panel: A Diagnostic Cohort Study","descripcion":"Importance: Blood biomarkers for Alzheimer disease(AD), Parkinson disease(PD), and amyotrophic lateral sclerosis(ALS) are typically developed as disease-specific single-analyte tests. Whether one shared plasma panel can support disease-selective classification remains unclear. Objective: To test whether the Olink Target 48 Neurodegeneration plasma panel, analyzed with disease-specific Elastic Net models, can discriminate AD, PD, and ALS in a heterogeneous neurological cohort. Design, Setting, and Participants: Single-center diagnostic cohort study at Keio University Hospital, Tokyo, Japan. After quality control and one consent withdrawal, 302 participants were analyzed(healthy controls n = 6","pubDate":"2026-10-21","url":"https://www.medrxiv.org/content/10.64898/2026.10.19.26365782v1?rss=1"},"indexado":"2026-10-22T04:37:56.220Z"}}